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US 2022/0017631 A1Published application
Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma
AssigneeEngmab SàRl
InventorsMinh Diem Vu, Klaus Strein, Bruno David Lourenco Paiva, Jesus Fernado San Miguel Izquierdo
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Abstract
The invention relates to a bispecific antibody specifically binding to human B cell maturation antigen (BCMA) and to human CD3ε (CD3) together with an immunotherapeutic drug for combined use in treating multiple myeloma.
Claims29
-10. (canceled)
A method of treating multiple myeloma comprising administering to a patient in need of such treatment a therapeutically effective amount of
- a) a bispecific antibody comprising a first binding part specifically binding to human B cell maturation antigen (BCMA) and a second binding part specifically binding to human CDR (CD3), wherein said first binding part comprises:
- a VH region comprising a CDR1H region of SEQ ID NO:21, a CDR2H region of SEQ ID NO:22 and a CDR3H region of SEQ ID NO:17 and a VL region comprising a CDR1L region of SEQ ID NO:27, a CDR2L region of SEQ ID NO:28 and a CDR3L region of SEQ ID NO:20;
- and,
- b) an immunotherapeutic drug selected from the group consisting of thalidomide or an immunotherapeutic derivative thereof, an anti-CD38 antibody, an anti-PD-1 antibody and an anti-PD-L1 antibody;
- wherein the bispecific antibody and the immunotherapeutic drug are administered separately or together.
2 more elements
Dependencies are inferred from the claim text.