Bispecific polypeptides for engagement of car expressing immune cells with antigen presenting cells and uses thereof
AssigneePeter MacCallum Cancer Institute
InventorsMichael Kershaw, Clare Slaney, Bianca Von Scheidt
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Abstract
The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.
Claims44
A bispecific polypeptide comprising a first binding domain and a second binding domain, wherein the first binding domain is an antibody or antibody fragment that specifically binds to an antigen expressed on an antigen presenting cell (APC), and wherein the second binding domain is an antibody or antibody fragment that specifically binds to an antigen on an immune cell expressing a chimeric antigen receptor (CAR).
Dependencies are inferred from the claim text.