Composition and Method for Regulating Migration of Immune Cells
OwnerJianfeng Chen, Changdong Lininventors
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Abstract
A composition and method for regulating the migration of immune cells. The method for regulating the migration of immune cells comprises the step of strengthening or weakening the interaction between Hsp90 and α4 integrin in immune cells. Also provided is an immune cell capable of strengthening or weakening the interaction between Hsp90 and α4 integrin and a pharmaceutical composition thereof. The present method and pharmaceutical composition may be used to treat pathogen infections and autoimmune diseases or to kill tumor cells.
Claims21
A method of regulating the migration of immune cells, comprising the step of enhancing or weakening the interaction between Hsp90 and α4 integrin in the immune cells.
A genetically engineered immune cell, having an enhanced or weakened interaction between Hsp90 and α4 integrin as compared with a wild-type immune cell.
A mutant Hsp90 protein selected from the group consisting of:
- (1) a mutant Hsp90 protein, lacking the N-terminal domain and/or the C-terminal domain of the wild-type Hsp90 protein;
- (2) a mutant Hsp90 protein, only having a mutation in the middle domain as compared with the wild-type Hsp90 protein while maintaining the ability to bind to α4 integrin as compared with the wild-type;
- and
- (3) a mutant Hsp90 protein, having a mutation causing its inability to self-dimerize as compared with the wild-type Hsp90 protein.
A mutant α4 integrin, wherein the mutant α4 integrin has one or more amino acid residues mutated in its intracellular segment other than amino acid residues 968-974, causing its interaction with Hsp90 protein weakened or eliminated.
(canceled)
Dependencies are inferred from the claim text.