Aavrh.10 variants with host antibody escape capabilities and altered tissue targeting properties
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsMavis Agbandje-McKenna, Mario Mietzsch
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Abstract
This disclosure relates to variant AAVrh 10 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.
Claims30
A recombinant adeno-associated virus rh.10 (rAAVrh.10) particle comprising a capsid protein comprising one or more mutations, wherein said mutations result in modulated reactivity to a neutralizing antibody and/or altered transduction efficiency relative to a wild-type AAVrh.10 particle having a capsid protein with an amino acid sequence of SEQ ID NO:
- 2.
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A capsid protein of serotype AAVrh.10 comprising one or more mutations in amino acid positions consisting of:
- S387, S453, S559, Q598, N590, A592, and T719 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.