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US 2022/0017570 A1Published application
Method for purifying pegylated protein
AssigneeBristol-Meyers Squibb Company
InventorsDeqiang YU, John PAGANO, Hasin FEROZ, Yuanli SONG, Sanchayita GHOSE, Zhengjian LI
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Abstract
This disclosure provides a novel method of purifying PEGylated proteins using ion exchange chromatography by loading PEGylated protein having a high concentration, e.g., at least 6 grams/liter on an ion exchange chromatography matrix, and collecting the PEGylated protein.
Claims34
A method for purifying a PEGylated protein, comprising loading PEGylated protein having a high concentration of at least 6 grams/liter on an ion exchange chromatography matrix, and collecting the PEGylated protein.
Dependencies are inferred from the claim text.