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US 2022/0017568 A1Published application
Linear solution phase routes for wnt hexapeptides
AssigneeWntresearch AB
InventorsTadikonda VEERABHADRA PRATAP, Kamaraju RAGHAVENDRA RAO, Dennis HENRIKSEN
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Abstract
The present disclosure relates generally to the field of polypeptide synthesis, and more particularly, to a linear solution phase synthesis of the Wnt hexapeptide Foxy-5 and protected derivatives and peptide fragments thereof.
Claims12
A hexapeptide derivative of the formula:
- PG-Met-Asp(OtBO-Gly-Cys(Trt)-
- Glu(OtBO-Leu-OR,
- wherein R is selected from C1-C6 alkyl, such as methyl or t-butyl, and PG is Fmoc.
Dependencies are inferred from the claim text.