Steroid derivative regulators, method for preparing the same, and uses thereof

A compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

• wherein:
• X is selected from the group consisting of —CR17— and —N—;
• Y is selected from the group consisting of —CR23R24—, —S(CH2)n1—, —P(CH2)n1—, —O(CH2)n1—, —(CH2)n1NR22—,
• Rx, Ry, Rz and Rf are identical or different and are each independently selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, amino, thiol, nitro, hydroxy, cyano, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1C(O)R23, —(CH2)n1C(O)OR23, —(CH2)n1S(O)m1R23, —(CH2)n1NR23R24, —(CH2)n1C(O)NR23R24, —(CH2)n1NR23C(O)R24 and —(CH2)n1NR23S(O)m1R24, wherein the alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, thiol, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —(CH2)n1R25, —(CH2)n1OR25, —(CH2)n1SR25, —(CH2)n1C(O)R25, —(CH2)n1C(O)OR25, —(CH2)n1S(O)m1R25, —(CH2)n1NR25R26, —(CH2)n1C(O)NR25R26, —(CH2)n1C(O)NHR25, —(CH2)n1NR25C(O)R26 and —(CH2)n1NR25S(O)m1R26;
• or, any two adjacent or non-adjacent groups or two identical groups of Rx, Ry, Rz and Rf are bonded to form a cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1C(O)R23, —(CH2)n1C(O)OR23, —(CH2)n1S(O)m1R23, —(CH2)n1NR23R24, —(CH2)n1C(O)NR23R24, —(CH2)n1NR23C(O)R24 and —(CH2)n1NR23S(O)m1R24;
• or, any two adjacent groups of Rx, Ry, Rz and Rf form a double bond;
• R21 is selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, amino, nitro, hydroxy, cyano, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1C(O)R23, —(CH2)n1C(O)OR23, —(CH2)n1S(O)m1R23, —(CH2)n1NR23R24, —(CH2)n1C(O)NR23R24, —(CH2)n1NR23C(O)R24 and —(CH2)n1NR23S(O)m1R24, wherein the alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —(CH2)n1R25, —(CH2)n1OR25, —(CH2)n1SR25, —(CH2)n1C(O)R25, —(CH2)n1C(O)OR25, —(CH2)n1S(O)m1R25, —(CH2)n1NR25R26, —(CH2)n1C(O)NR25R26, —(CH2)n1C(O)NHR25, —(CH2)n1NR25C(O)R26 and —(CH2)n1NR25S(O)m1R26;
• when X is —CR17—, then R17 is selected from the group consisting of a bond, hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, hydroxy, amino, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally substituted by one or more substituents selected from the group consisting of deuterium atom, substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted amino, oxo, nitro, cyano, alkenyl, alkynyl, alkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• or, R17 and any group of Rx, Ry, Rz and Rf are bonded to form a cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1C(O)R23, —(CH2)n1C(O)OR23, —(CH2)n1S(O)m1R23, —(CH2)n1NR23R24, —(CH2)n1C(O)NR23R24, —(CH2)n1NR23C(O)R24 and —(CH2)n1NR23S(O)m1R24;
• R22 is selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, amino, nitro, hydroxy, cyano, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1C(O)R23, —(CH2)n1C(O)OR23, —(CH2)n1S(O)m1R23, —(CH2)n1NR23R24, —(CH2)n1C(O)NR23R24, —(CH2)n1NR23C(O)R24 and —(CH2)n1NR23S(O)m1R24, wherein the alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —(CH2)n1R25, —(CH2)n1OR25, —(CH2)n1SR25, —(CH2)n1C(O)R25, —(CH2)n1C(O)OR25, —(CH2)n1S(O)m1R25, —(CH2)n1NR25R26, —(CH2)n1C(O)NR25R26, —(CH2)n1C(O)NHR25, —(CH2)n1NR25C(O)R26 and —(CH2)n1NR25S(O)m1R26;
• R23, R24, R25 and R26 are identical or different and are each independently selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, hydroxy, amino, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally substituted by one or more substituents selected from the group consisting of deuterium atom, substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted amino, oxo, nitro, cyano, alkenyl, alkynyl, alkoxy, hydroxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• m is an integer of 0, 1, 3, 4, 5, 6, 7, 8, 9 or 10;
• n is an integer of 0, 1, 2 or 3;
• o is an integer of 0, 1, 2, 3, 4 or 5;
• p is an integer of 0, 1, 2, 3, 4, 5 or 6;
• q is an integer of 0, 1, 2, 3, 4, 5 or 6;
• m1 is an integer of 0, 1 or 2;
• and
• n1 is an integer of 0, 1, 2, 3, 4 or 5.