Cyclic dinucleotides for cytokine induction
AssigneeKayla Therapeutics
InventorsFabienne VERNEJOUL, Gerard TlRABY, Thierry LIOUX
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Abstract
A cyclic dinucleotide compound of Formula (I): wherein X1 is H or F; X2 is H or F; at least one among X1 and X2 is a fluorine atom; Z is OH, OR1, SH or SR1, wherein: R1 is Na or NH4, or R1 is an enzyme-labile group which provides OH or SH in vivo such as pivaloyloxymethyl; B1 and B2 are bases chosen from Adenine, Hypoxanthine or Guanine, and B1 is a different base than B2 and a pharmaceutically acceptable salt thereof. Pharmaceutical compositions including the cyclic dinucleotide, as well as their use in the treatment of a bacterial infection, a viral infection or a cancer are also described.
Claims21
1-12. (canceled)
A method of treating cancer in a subject in need thereof, comprising administering a compound represented by the following formula or a pharmaceutically acceptable salt thereof:
A method of treating cancer in a subject in need thereof, comprising administering a pharmaceutical composition comprising a compound represented by the following formula or a pharmaceutically acceptable salt thereof:
- in combination with an immune agent, which is an antibody.
Dependencies are inferred from the claim text.