Substituted pyrazolo[1,5-a]pyridine compound, composition containing the same and use thereof
AssigneeShenzhen TargetRx, Inc.
InventorsYihan Wang, Xingye Ren
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Abstract
The present disclosure provides a substituted pyrazolo[1,5-a]pyridine compound, a composition including the same, and a use thereof. The substituted pyrazolo[1,5-a]pyridine compounds is a compound represented by formula (I) or the tautomers, stereoisomers, prodrugs, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof. The compound of the present disclosure and composition thereof are useful for treating RET kinase-mediated diseases or conditions and have more excellent pharmacokinetic properties.
Claims20
A compound of formula (I), or the tautomers, stereoisomers, prodrugs, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof:
- wherein,
- Y is selected from CH or N, which is optionally substituted by deuterium, halogen or trifluoromethyl;
- W is CR9R10;
- R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are each independently selected from hydrogen or deuterium;
- Y1, Y2, Y3, Y4, Y5, Y6, Y7 and Y8 are each independently selected from hydrogen, deuterium, halogen or trifluoromethyl;
- X is selected from CH3, CD3, CHD2 or CH2D;
- Z is selected from:
- which is optionally substituted by 1, 2, 3, 4, 5, 6, 7, 8 or 9 deuterium;
- *represents the bond connected to the core;
- provided that the above compound has at least one deuterium atom.
Dependencies are inferred from the claim text.