Crystalline forms of a mcl-1 inhibitor, a process for their preparation and pharmaceutical compositions containing them
AssigneesLes Laboratoires Servier, Vernalis (R&D) Ltd
InventorsEmilie DE BAETS, Julien AUVRAY, Michael LYNCH, Nicolas LEBLANC
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Abstract
Crystalline forms of Compound A: characterized by its X-ray powder diffraction diagram, solid-state 13C NMR spectrum. MIR spectrum and Raman spectrum and pharmaceutical compositions containing it.
Claims29
1-31. (canceled)
A crystalline Form M of 2-{[5-{3-Chloro-2-methyl-4-[2-(4-methylpiperazine-1-yl) ethoxy]phenyl}-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl)propanoic acid (Compound A).
A crystalline Form A of 2-{[5-{3-Chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl) ethoxy]phenyl}-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl)propanoic acid (Compound A).
Dependencies are inferred from the claim text.