Method for preparing pyrrolopyrimidine compound and application thereof
AssigneesCinkate Pharm Tech (Shanghai) Co., Ltd., Cinkate Pharmaceutical Intermediates Co., Ltd.
InventorsNa LIU, Lixia BAO, Zhepeng WEI, Yufeng ZHOU, Bin RONG, Lihui ZHAO, Fei XIAO
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Abstract
The present invention provides a method for preparing a pyrrolopyrimidine compound and application thereof. Specifically, the present invention provides a compound represented by formula I or pharmaceutically-acceptable salts thereof, a pharmaceutical composition containing the compound or its salts, and a method for preparing the pharmaceutical composition and an application of the pharmaceutical composition as an immunosuppressive drug.
Claims11
A compound of formula I, or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 is selected from the group consisting of H, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C4-C10 heterocyclic group, substituted or unsubstituted C1-C10 heteroaryl group, —RaC(O)Rb, —R1′—NRcC(O)Rb, and —R1′—N═CRcRb;
- and the substitution means having one or more substituents selected from the group consisting of substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C4-C10 heterocyclic group, substituted or unsubstituted C1-C10 heteroaryl, halogen, —NH2, —OH and —CN;
- each Ra and Rb is independently selected from the group consisting of hydrogen, —CN, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C3-C8 alkynyl, substituted or unsubstituted C6-C10 aryl group, substituted or unsubstituted C3-C10 cycloalkyl group, substituted or unsubstituted C4-C10 heterocyclic group, and substituted or unsubstituted C1-C10 heteroaryl group, and the substitution means having one or more substituents selected from the group consisting of halogen, amino, nitro, —OH, —CN, C1-C4 alkyl and C1-C4 haloalkyl;
- Re is H or C1-C3 alkyl group;
- R1′ is phenyl or cyclohexyl;
- wherein the C4-C10 heterocyclic group and the C1-C10 heteroaryl group each independently has 1 to 3 hetero atoms selected from the group consisting of N, O, and S.
Dependencies are inferred from the claim text.