Macrocyclic compound as cdk inhibitor, preparation method therefor, and use thereof in medicine

A compound of formula (I):

• or a tautomer, mesomer, racemate, enantiomer, diastereomer thereof, or mixture thereof, or a pharmaceutically acceptable salt thereof,
• wherein:
• A and B are each independently selected from the group consisting of CH and N atom;
• U, V, W, X and Y are each independently selected from the group consisting of CH and N atom;
• Q is selected from the group consisting of a bond, C1-4 alkylene and —C(═O)—, wherein the C1-4 alkylene is optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano;
• G is selected from the group consisting of a bond, —O—, —N(R7)—, —C(═O)—, C1-4 alkylene, C2-4 alkenyl, —S—, —SO—, —SO2— and 3 to 6 membered heterocyclyl, wherein the C1-4 alkylene, C2-4 alkenyl and 3 to 6 membered heterocyclyl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano;
• J is selected from the group consisting of a bond, —O—, —N(R7)—, —C(═O)—, C1-4 alkylene, C2-4 alkenyl, —S—, —SO—, —SO2— and 3 to 6 membered heterocyclyl, wherein the C1-4 alkylene, C2-4 alkenyl and 3 to 6 membered heterocyclyl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano;
• L is selected from the group consisting of a bond, —C(═O)—, C1-4 alkylene, C2-4 alkenyl, —S—, —SO—, —SO2— and 3 to 6 membered heterocyclyl, wherein the C1-4 alkylene, C2-4 alkenyl and 3 to 6 membered heterocyclyl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano;
• R1 is selected from the group consisting of H atom, C1-4 alkyl, cyano, C2-4 alkenyl and C2-4 alkynyl, wherein the C1-4 alkyl, C2-4 alkenyl and C2-4 alkynyl are each independently optionally substituted by one or more substituents selected from the group consisting of halogen, amino, nitro, hydroxy and cyano;
• R2 is selected from the group consisting of H atom and C1-4 alkyl, wherein the C1-4 alkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, amino, nitro, hydroxy and cyano;
• or, R1 and R2 together with the atom to which they are attached form a C3-6 cycloalkyl or 3 to 6 membered heterocyclyl, wherein the C3-6 cycloalkyl or 3 to 6 membered heterocyclyl are each independently optionally substituted by one or more substituents selected from the group consisting of C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano;
• R3 and R6 are each independently selected from the group consisting of H atom and C1-4 alkyl, wherein the alkyl is optionally substituted by one or more substituents selected from the group consisting of C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano;
• R4 and R5 are each independently selected from the group consisting of H atom, C1-4 alkyl, halogen, hydroxy and C1-4 alkoxy, wherein the C1-4 alkyl and C1-4 alkoxy are each independently optionally substituted by one or more substituents selected from the group consisting of halogen, amino, nitro, hydroxy and cyano;
• and
• R7 is selected from the group consisting of H atom and C1-4 alkyl, wherein the alkyl is optionally substituted by one or more substituents selected from the group consisting of C1-4 alkoxy, haloC1-4 alkoxy, halogen, amino, nitro, hydroxy and cyano.