Six-membered and six-membered heterocyclic compound and uses thereof serving as protein receptor kinase inhibitor

A compounds of Formula I:

• wherein,
• X is H, halogen, D, CN or —CONH2;
• X1 is CR or N;
• R is selected from the group consisting of H, D, fluorine, chlorine, —OH, —NH2;
• L1 is selected from the group consisting of a substituted or unsubstituted 5-10 membered heterocycloalkylene group comprising 1-3 heteroatoms selected from N, S or O, or a substituted or unsubstituted —(X3)y—, wherein each X3 is independently selected from the group consisting of:
• a substituted or unsubstituted C1-C8 alkylene group, —O—, —C(═O)—, —CONH—, —NHCO—, —S—, —S(═O)—, —S(═O)2— and —NH—;
• L2 is selected from the group consisting of a substitution or unsubstituted —(X4)z—, wherein each X4 is independently selected from the group consisting of a substituted or unsubstituted C1-C8 alkylene, —O—, —C(═O)—, —S—, —S(═O)—, —S(═O)2—, —NH—, —CONH—, —NHCO—, —NHCS—, —NHCONH—, —NHS(═O)—, —NHS(═O)2—;
• y is selected from 1 or 2;
• Z is selected from 0, 1 or 2;
• RA is selected from the group consisting of H, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 5-10 membered heteroaryl comprising 1-3 heteroatoms selected from N, S or O;
• RB is selected from the group consisting of H, NH2, OH, —COOH, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C1-C8 alkoxy, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 5-10 membered heteroaryl comprising 1-3 heteroatoms selected from N, S or O, substituted or unsubstituted 5-10 membered heterocyclic group comprising 1-3 heteroatoms selected from N, S or O (including a monocyclic, bicyclic, spiro or bridged ring);
• unless otherwise specified, the “substituted” means that a group is substituted by one or more (e.g., 2, 3, 4, etc.) substituents selected from the group consisting of a halogen, C1-C6 alkoxy, halogenated C1-C6 alkyl, halogenated C1-C6 alkoxy, halogenated C3-C8 cycloalkyl, methyl sulfuryl, —S(═O)2NH2, oxo (═O), —CN, hydroxy, —NH2, carboxyl, C1-C6 amido (—C(═O)—N(Rc)2 or —NH—C(═O)(Rc), Rc is H or C1-C5 alkyl), C1-C6 alkyl-(C1-C6 amido),
• or a substituted or unsubstituted group selected from the group consisting of a C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 amido, C6-C10 aryl, 5-10 membered heteroaryl comprising 1-3 heteroatoms selected from N, S, or O, 3-12 membered heterocyclic ring group comprising 1-3 heteroatoms selected from N, S or O (including a monocyclic, bicyclic, spiro or bridged ring), —(CH2)—C6-C10 aryl, —(CH2)-(5-10 membered heteroaryl comprising 1-3 heteroatoms selected from N, S, or O), wherein the substituent is selected from the group consisting of a halogen, C1-C6 alkoxy, halogenated C1-C6 alkyl, halogenated C1-C6 alkoxy, halogenated C3-C8 cycloalkyl, methyl sulfuryl, —S(═O)2NH2, oxo (═O), —CN, hydroxyl, —NH2, carboxyl, C1-C6 amido (—C(═O)—N(Rc)2 or —NH—C(═O)(Rc), Rc is H or C1-C5 alkyl), C1-C6 alkyl-(C1-C6 amido),
• C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 amine group, C6-C10 aryl, 5-10 membered heteroaryl comprising 1-3 heteroatoms selected from N, S, or O, 3-12 membered heterocyclic ring group comprising 1-3 heteroatoms selected from N, S or O (including a monocyclic, bicyclic, spiro or bridged ring), —(CH2)—C6-C10 aryl, —(CH2)-(5-10 membered heteroaryl comprising 1-3 heteroatoms selected from N, S, or O);
• is the connection site of the group;
• with the proviso that compounds of formula I are chemical stable structures.