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US 2022/0017484 A1Published application
Inhibitor of bruton tyrosine kinase
AssigneeBeijing Reciprocapharmaceuticals Co. Ltd.
InventorsZhengying Pan, Zhaodong Jiao, Xitao Li, Guanyu Tao, Yanxia Shi, Rui Zhang
Life of this patent
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Abstract
Disclosed herein is a compound of Formula (I) with a Btk inhibitory activity, wherein all the variables are as defined herein. The compound can be used for the treatment of diseases such as autoimmune diseases, xenogeneic immune diseases, cancers or thromboembolic diseases. Also disclosed is a pharmaceutical composition comprising a compound of Formula (I). Further provided is a compound capable of inhibiting the activity of Bruton's tyrosine kinase by covalent binding.
Claims22
A compound of Formula (I):
- wherein,
- W is selected from the group consisting of H, C1-6alkyl, aryl optionally substituted with halogenated C1-3alkyl or a five- to seven-membered nitrogen-containing aliphatic ring, heteroaryl, and —C(O)—R3, wherein R3 is C1-3alkyl, di(C1-3alkyl)amino, or C1-3alkoxy optionally substituted with aryl;
- X is selected from the group consisting of halo and C1-6alkyl, and X is bonded to any bondable position on the pyridone ring;
- Y is selected from the group consisting of H, halo, C1-6alkyl, and C1-3alkoxy optionally substituted with C1-3alkoxy;
- R1 and R2 are independently the same or different, and are selected from the group consisting of H, C1-3alkyl optionally substituted with C1-3alkoxy or di(C1-3alkyl)amino, C(O), S(O), and S(O)2;
- L1 and L2 are independently the same or different, and are selected from the group consisting of C1-6alkyl optionally substituted with —NR4R5, C2-3alkenyl optionally substituted with halo or optionally substituted C1-3alkyl, and C2-3alkynyl optionally substituted with C1-3alkyl, wherein the substituent of the optionally substituted C1-3alkyl is di(C1-3alkyl)amino, or a five- to seven-membered nitrogen-containing aliphatic ring;
- and
- R4 and R5 in —NR4R5 are independently the same or different, and are selected from the group consisting of H, C1-3alkyl, and C2-3alkenylcarbonyl, or one of R4 and R5, and one carbon atom in the C1-6alkyl optionally substituted with —NR4R5, together with the atom to which they are bonded, form a five- to seven-membered nitrogen-containing aliphatic ring,
- provided that when R1 is H, or C1-3alkyl optionally substituted with C1-3alkoxy or di(C1-3alkyl)amino, L1 is absent, and when R2 is H, or C1-3alkyl optionally substituted with C1-3alkoxy or di(C1-3alkyl)amino, L2 is absent,
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.