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US 2022/0017451 A1Published application
Preparation of chiral primary amine from asymmetric reductive amination of simple ketone catalyzed by ruthenium-diphosphine catalyst
AssigneesShenzhen Catalys Technology Co., Ltd, Shenzhen Innovation Center of Small Molecule Drug Discovery Co., Ltd.
InventorsQiwei LANG, Xiaobing DING, Shaobai YAN
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Abstract
The present invention relates to a preparation method of chiral primary amine. The chiral primary amine is prepared through a one-pot method that under the action of a ruthenium-chiral diphosphine catalyst, a simple ketone and an ammonium salt RCOONH4 have reductive amination by adding hydrogen and then are heated and hydrolyzed by adding acid. The present invention has the advantages of good substrate universality, high reaction efficiency and the like
Claims20
A preparation method of chiral primary amine, comprising:
- making a ketone compound and an ammonium salt, used as raw materials, react under the action of an organic solvent, hydrogen and a ruthenium-diphosphine catalyst to generate an intermediate, and performing acid adding and heating hydrolysis treatment on the intermediate to obtain the chiral primary amine.
Dependencies are inferred from the claim text.