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US 2022/0016624 A1Published application
Compositions, methods and systems for sample processing
AssigneeReadcoor, LLC
InventorsEvan Daugharthy, Richard Terry, Hong Chen, Ben Pruitt, Gene Daidone, Vikki Asman, Adrian Tanner, Eric Evje
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Abstract
The present disclosure provides compositions and methods for making and using a support (e.g., a sample slide) for sample analysis. The present disclosure also provides compositions, methods, and systems for processing a sample on the support for use in nucleic acid sequence detection.
Claims21
-189. (canceled)
A system for analyzing a sample comprising:
- a first module having a first housing comprising:
- a first stage configured to retain a sample comprising a plurality of nucleic acid molecules in a three-dimensional (3D) matrix, which plurality of nucleic acid molecules have a relative 3D spatial relationship;
- and
- a detector configured to detect one or more signals from the sample;
- and
- a second module having a second housing comprising:
- a computer operatively coupled to the detector, wherein the computer is configured to:
- (a) bring said plurality of nucleic acid molecules or derivatives thereof in contact with detectable moieties, and use said detector to obtain signals corresponding to said detectable moieties from a plurality of planes of said 3D matrix, and
- (b) use said signals obtained by said detector to generate a 3D volumetric representation of said plurality of nucleic acid molecules, which 3D volumetric representation identifies said relative 3D spatial relationship of said plurality of nucleic acid molecules;
- and
- a second stage,
- wherein the first housing is physically distinct from the second housing.
9 more elements
Dependencies are inferred from the claim text.