3-dimensional large capacity cell encapsulation device assembly
AssigneeViaCyte, Inc.
InventorsVincent So, Laura Martinson, Chad Green, Michael Scott, Mario Zamarripa
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Abstract
Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
Claims20
A device comprising:
- a) a continuous chamber comprising at least one bend, wherein the continuous chamber is a continuous tube;
- and
- b) living mammalian cells that are dispersed within the chamber, wherein the cells comprise definitive endoderm-lineage cells, pancreatic and duodenal homeobox gene 1 (PDX1)-positive pancreatic progenitor cells, endocrine precursor cells, or immature beta cells,
- wherein the chamber comprises a matrix with a plurality of interconnected cavities or pores.
A cell encapsulation assembly, said assembly comprising three or more planar cell chambers and cell-free regions along the longest axis separating adjacent planar cell chambers, wherein each chamber is fluidly separated from another chamber, and each chamber comprises a semi-permeable membrane comprising an inner surface configured to be in contact with cells that are placed in the respective chamber, wherein each chamber has at least one loading port extending from outside of the chamber to inside of the chamber, wherein each chamber is configured to be sealed to contain the cells that are placed in the respective chamber, and at least a portion of an outer surface of the cell encapsulating assembly is configured to be placed in direct contact with host tissue upon implantation of the cell encapsulating assembly into a mammalian host, and wherein each assembly comprises at least two tabs or openings for securing the assembly at an implantation site inside the host.
Dependencies are inferred from the claim text.