Intravascular devices and methods for delivery of fluids and therapeutic agents into blood vessel walls and intravascular structures
AssigneeInterVene, Inc.
InventorsFletcher T. Wilson, Jeffrey M. Elkins, Kent D. Dell, Herbert Mendoza, Michi E. Garrison
Life of this patent
Estimating the term…
Abstract
Intravascular devices and methods for intramural delivery of dissection fluids and infusates are disclosed herein. In some embodiments, the systems include an infusion assembly that can access a vessel wall at a depth within a layer of the vessel wall and advance a tissue manipulation component at approximately the same depth within the vessel wall to create an intramural space within the vessel layer. The infusion assembly can further deliver an infusate that includes a therapeutic drug or other agent into the intramural space.
Claims21
An infusion device, comprising:
- a handle assembly;
- a catheter shaft having a proximal end portion coupled to the handle assembly and a distal end portion, wherein the catheter shaft includes:
- a lumen extending from the proximal end portion to the distal end portion;
- a housing at the distal end portion having an exit port in communication with the lumen, a transition surface adjacent the exit port, and an offset surface distal to the exit port, wherein the exit port is spaced apart from the offset surface by a distance, and wherein the transition surface and the offset surface are configured to contact and at least partially conform a tissue wall to a shape of the transition surface and the offset surface
- a height adjustment component configured to adjust the distance between the exit port and the offset surface;
- and
- an expandable component at the distal end portion configured to press the transition surface and the offset surface against the tissue wall;
- and
- a tissue penetrating component slidably positioned within the lumen, the tissue penetrating component configured to create a space within the tissue wall and deliver an infusate into the space.
An infusate delivery system, comprising:
- a handle assembly comprising a fluid control valve;
- a catheter shaft having a proximal portion coupled to the handle assembly, a distal portion opposite the proximal portion, and a lumen extending through the catheter shaft, wherein the distal portion comprises—
- a housing having at least one engagement surface configured to engage a vessel wall at a target site;
- an exit port in communication with the lumen;
- and
- an expandable component carried by the housing and opposite the at least one engagement surface;
- and
- a tissue manipulation device slidably positioned within the lumen, the tissue manipulation device configured to manipulate the vessel wall to access an intramural space of the vessel wall and deliver an infusate into the vessel wall,
- wherein the fluid control valve is controllable to alter a fluid supplied to the tissue manipulation device between a dissection fluid supply and an infusate supply.
A method of intravascularly delivering a therapeutic agent to a target site, the method comprising:
- positioning a distal portion of a catheter shaft of an infusion device at a target site within a vein of a patient;
- pressing an engagement surface of a housing at the distal end of the catheter shaft against a venous wall such that the venous wall conforms to the engagement surface;
- extending a needle of the infusion device through an exit port at the distal portion of the catheter shaft to penetrate the venous wall at the target site to access intramural space within the venous wall;
- moving the needle within the intramural space in a direction generally aligned with a longitudinal axis of the catheter shaft;
- and
- delivering, through the needle, a drug to the intramural space within the venous wall.
A method of intravascularly delivering a therapeutic agent to a patient diagnosed with deep vein thrombosis, the method comprising:
- positioning a distal portion of a catheter device at a target site within a vein of the patient;
- penetrating a venous wall at the target site with a needle of the catheter device to access perivascular space adjacent to an outer surface of the venous wall;
- and
- delivering a drug to prevent post thrombotic syndrome.
Dependencies are inferred from the claim text.