Tissue scaffold materials for tissue regeneration and methods of making
AssigneeCornell University
InventorsJason SPECTOR, Abraham D. STROOCK, John MORGAN
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Abstract
Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.
Claims22
A tissue scaffold material comprising a hydrogel and microspheres, said hydrogel comprising a first polymer and said microspheres comprising a second polymer, wherein said microspheres are embedded in said hydrogel, and said microspheres have a greater density than said hydrogel.
-14. (canceled)
A method of making a tissue scaffold material, comprising the steps of:
- a. providing a first composition comprising microspheres, and a second composition comprising a polymer material, the first composition having a different density than the second composition;
- b. mixing the first and second compositions;
- and
- c. causing crosslinking of the polymer material in said mixture, to form a hydrogel with embedded microspheres.
-30. (canceled)
Dependencies are inferred from the claim text.