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US 2022/0016261 A1Published application
Pyrrolobenzodiazepine-antibody conjugates
AssigneesAdc Therapeutics SA, MedImmune, LLC
InventorPatricius Hendrikus Cornelis VAN BERKEL
Life of this patent
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Abstract
The present disclosure relates to pyrrolobenzodiazepines (PBDs) having a labile C2 or N10 protecting group in the form of a linker to an antibody.
Claims18
-122. (canceled)
A conjugate of formula ConjE:
- wherein Ab is an antibody that binds to kidney associated antigen 1 (KAAG1), the antibody comprising a VH domain comprising a VH CDR1 amino acid sequence of SEQ ID NO. 5, a VH CDR2 amino acid sequence of SEQ ID NO. 6, and a VH CDR3 amino acid sequence of SEQ ID NO. 7;
- and
- wherein the drug loading (p) is from 1 to 8.
A method of treating a kidney associated antigen 1 (KAAG1)-overexpressing cancer in a patient comprising administering to the patient the conjugate of claim 1.
Dependencies are inferred from the claim text.