Conjugate of biotin-modified dimer and phthalocyanine dye
AssigneesThe University of Tokyo, Savid Therapeutics Inc.
InventorsMotomu KANAI, Kenzo YAMATSUGU, Toshifumi TATSUMI, Kazuki TAKAHASHI, Tatsuhiko KODAMA, Toshiya TANAKA, Takefumi YAMASHITA, Akira SUGIYAMA, Masanobu TSUKAGOSHI
Life of this patent
Estimating the term…
Abstract
It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy. The present invention provides a conjugate of a compound represented by the following formula (1) or a salt thereof and a phthalocyanine dye: wherein the meaning of each of symbols is as defined in the specification.
Claims13
A conjugate of a compound represented by the following formula (1) or a salt thereof and a phthalocyanine dye:
- wherein:
- X1a, X1b, X2a and X2b each independently represent O or NH,
- Y1 and Y2 each independently represent C or S,
- Z1 and Z2 each independently represent O, S or NH,
- V1 and V2 each independently represent S or S+—O−,
- n1 and n2 each independently represent an integer of 0 or 1,
- L1 and L2 each independently represent a divalent linking group,
- L3 represents a group comprising a functional group capable of binding to a phthalocyanine dye at the terminus, and
- L4 represents a trivalent linking group.
A conjugate represented by any one of the following:
Dependencies are inferred from the claim text.