Methods for making mixed allergen compositions
AssigneeAlladapt Immunotherapeutics, Inc.
InventorsOlivia M. Weihe, Christopher Cornyn, Ashley Dombkowski, Dana McClintock
Life of this patent
Estimating the term…
Abstract
Methods of making mixed allergen drug products are provided, wherein the mixed allergen drug products are of known potency and identity and substantially free of replication viable organisms.
Claims49
A method of making a sterile mixed allergen drug product with known potency and identity that is substantially free of replication viable organisms, the method comprising:
- separately irradiating each of 2 to 20 different raw complete food allergen substances, wherein irradiating comprises applying ionizing radiation to each individual raw complete food allergen substance, thereby producing 2 to 20 individual allergen drug substances each substantially free of replication viable organisms, and wherein each individual allergen drug substance retains substantially intact, allergenic proteins;
- and
- blending the 2 to 20 individual allergen drug substances together, thereby obtaining the mixed allergen drug product.
A method of making a sterile mixed allergen drug product substantially free of replication viable organisms, the method comprising:
- providing 2 to 20 individual irradiated allergen drug substances each substantially free of replication viable organisms and wherein each individual allergen drug substance retains substantially intact, allergenic proteins;
- and
- blending the 2 to 20 individual allergen drug substances together, thereby obtaining the mixed allergen drug product.
A method of making a mixed allergen drug product substantially free of replication viable organisms, the method comprising:
- providing 6 to 20 different raw complete food allergen substances;
- blending the 6 to 20 different raw complete food allergen substances to produce a bulk substance;
- and
- irradiating the bulk substance with ionizing radiation,
- thereby obtaining the mixed allergen drug product.
A method of making a sterile allergen drug product substantially free of replication viable organisms, the method comprising:
- irradiating a raw complete food allergen substance, wherein irradiating comprises applying ionizing radiation to the raw complete food allergen substance, thereby producing an individual allergen drug substance substantially free of replication viable organisms and wherein the allergen drug substance retains substantially intact, allergenic proteins.
Dependencies are inferred from the claim text.