Immunogenic Multiple Hetero-Antigen Polysaccharide-Protein Conjugates and uses thereof
AssigneePfizer Inc.
InventorsAvvari Krishna Prasad, Jianxin Gu, Jin-Hwan Kim, Suddham Singh
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Abstract
The present invention relates to new glycoconjugates comprising Streptococcus pneumoniae capsular saccharide antigens and uses thereof. Glycoconjugates of the present invention will typically comprise 2 or more saccharides antigens conjugated to the same molecule of the protein carrier. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using immunogenic compositions comprising said novel glycoconjugates.
Claims23
A glycoconjugate comprising at least two saccharides selected from the group consisting of a saccharide from S. pneumoniae serotype 10A, a saccharide from S. pneumoniae serotype 22F, a saccharide from S. pneumoniae serotype 33F and a saccharide from S. pneumoniae serotype 35B, conjugated to the same carrier protein.
A glycoconjugate comprising at least two saccharides selected from the group consisting of a saccharide from S. pneumoniae serotype 8, a saccharide from S. pneumoniae serotype 11A, a saccharide from S. pneumoniae serotype 12F, a saccharide from S. pneumoniae serotype 23A and a saccharide from S. pneumoniae serotype 23B, conjugated to the same carrier protein.
A glycoconjugate comprising at least two saccharides selected from the group consisting of a saccharide from S. pneumoniae serotype 8, a saccharide from S. pneumoniae serotype 15A, a saccharide from S. pneumoniae serotype 15B, a saccharide from S. pneumoniae serotype 23A and a saccharide from S. pneumoniae serotype 23B, conjugated to the same carrier protein.
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Dependencies are inferred from the claim text.