Hydrogel composition and associated method of use
AssigneeQuthero, Inc.
InventorsMilica RADISIC, Yun XIAO, Lewis REIS, Serena MANDLA
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Abstract
The invention provides a composition and pharmaceutical formulation including a peptide immobilized in a hydro gel. Compositions and formulations of the invention are useful in reducing the size, severity or duration of a wound, ameliorating of one or more symptoms associated with a wound without necessarily curing the wound, or lessening in the growth or severity of a wound. Compositions and formulations of the invention are particularly useful in the treatment of a wound associated with diabetes, such as a diabetic ulcer.
Claims20
A method of treating an epithelial wound in a patient in need there of, the method comprising administering topically to the epithelial wound of the patient a formulation comprising a biomaterial and at least one peptide of the formula:
- X1 X2 X3 X4X5X6 X7 wherein:
- X1 is an optional residue selected from glutamine, threonine, serine or asparagine;
- X2 is an optional positively charged residue selected from histidine, arginine or lysine;
- X3 is glutamate, threonine, isoleucine, histidine, lysine, glutamine, tyrosine, valine or leucine;
- X4 is glycine or valine;
- X5 is an optional residue selected from serine, threonine, aspartic acid, isoleucine or glycine;
- X6 is an optional residue selected from leucine, valine, glutamine,
- glycine, isoleucine or serine;
- and
- X7 is an optional residue selected from aspartic acid, asparagine, valine or lysine;
- and wherein the method is effective for treating the epithelial wound.
The method of 15, wherein the QHREDGS (SEQ ID NO.:1) peptide is present in the biomaterial is at a concentration of about 75 μM to about 750 μM.
A method of treating an epithelial wound in a patient in need thereof, the method comprising administering topically to the epithelial wound of said patient a formulation comprising a hydrogel and a peptide having the sequence QHREDGS (SEQ ID NO.:1), wherein the peptide is immobilized to the hydrogel, and wherein the method is effective for treating the epithelial wound.
Dependencies are inferred from the claim text.