Methods for disrupting biofilms
OwnerZvi HAYOUKAinventor
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Abstract
The present invention provides methods for disrupting biofilms and/or preventing the formation of biofilms along with medical items that contain a coating or covering made of compositions for achieving such disruption or prevention. In particular, the compositions of the present invention provide random-sequence peptide mixtures for use in disrupting bacterial biofilms; the random-sequence peptides having hydrophobic and/or cationic amino acids, wherein the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
Claims20
An item configured to prevent biofilm formation, disrupt biofilm and/or prevent microbial contamination, wherein the item includes a coating or covering of a composition comprising a mixture of a plurality of random-sequence peptides, wherein the peptides have an identical number of amino acid residues and a length of 10 to 40 amino acid residues, wherein the mixture of peptides consists of one or more species of hydrophobic amino acids in an L- or D-configuration and one or more species of cationic amino acids in an L- or D-configuration, wherein the ratio in the mixture of the total hydrophobic and cationic amino acids is about 3:1 to 1:3, and wherein the mixture of the plurality of random-sequence peptides contains 210 up to millions of sequences.
A method for preventing biofilm formation, disrupting a biofilm and/or preventing microbial contamination comprising applying to a surface of an item a composition comprising a mixture of a plurality of random-sequence peptides, wherein the peptides have an identical number of amino acid residues and a length of 10 to 40 amino acid residues, wherein the mixture of peptides consists of one or more species of hydrophobic amino acids in an L- or D-configuration and one or more species of cationic amino acids in an L- or D-configuration, wherein the ratio in the mixture of the total hydrophobic and cationic amino acids is about 3:1 to 1:3, and wherein the mixture of the plurality of random-sequence peptides contains 210 up to millions of sequences.
Dependencies are inferred from the claim text.