US 2022/0016196 A1 · Aloe Based Compositions Comprising Polysaccharides and Polyphenols for Regulation of Homeostasis of Immunity

Abstract

Compositions used and methods are disclosed for regulation of immunity homeostasis including a combination of an Aloe extract enriched for one or more polysaccharides; a Poria extract enriched for one or more polysaccharides; and a Rosemary extract enriched for one or more polyphenolic compounds. Compositions for maintenance of immunity homeostasis by regulating HMGB1, comprising a combination of one or more polysaccharides and one or more polyphenolic compounds are disclosed. Methods for treating, managing, promoting regulation of immunity homeostasis in a mammal are disclosed that include administering an effective amount of a composition from 0.01 mg/kg to 500 mg/kg body weight of the mammal.

Claims49

Dependent claims

A composition for regulation of immunity homeostasis, comprising a combination of an Aloe extract enriched for one or more polysaccharides;

a Poria extract enriched for one or more polysaccharides;
and a Rosemary extract enriched for one or more polyphenolic compounds.

A composition for maintenance of immunity homeostasis by regulating HMGB1, comprising a combination of one or more polysaccharides and one or more polyphenolic compounds, wherein the composition modulates HMGB1 by inhibition of HMGB1 release or counteract its action as targeting HMGB1 active or passive release by blocking cytoplasm translocation, or by blocking vesicle mediated release;

or inhibiting intramolecular disulfide bond formation in the nucleus;
or targeting HMGB1 directly upon release and neutralize its effect;
or blocking HMGB1 pattern recognizing receptors such as Toll-like Receptor (TLR)-2/4/7/9 and receptor for advanced glycation end products (RAGE) or inhibiting their signal transductions;
or changing the physiochemical microenvironment and preventing formation of HMGB1 tetramer and interfere the binding affinity of HMGB1 to TLR and RAGE;
or preventing cluster formation or self-association of HMGB 1.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/370,200Filed 8 Jul 2021

Priority

9 Jul 2020

Published

20 Jan 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 36/886
Liliopsida: aloeaceae , e.g. aloe vera
A23L 33/105
Using additives: plant extracts, their artificial duplicates or their derivatives
A61K 31/05
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates: phenols
A61K 31/352
Having six-membered rings with one oxygen as the only ring hetero atom: condensed with carbocyclic rings, e.g. methantheline

Aloe Based Compositions Comprising Polysaccharides and Polyphenols for Regulation of Homeostasis of Immunity

Life of this patent

Aloe Based Compositions Comprising Polysaccharides and Polyphenols for Regulation of Homeostasis of Immunity

Life of this patent

Abstract

Claims49