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AssigneesBoard of Regents, The University of Texas System, Institut Gustave Roussy
InventorsJennifer A. WARGO, Vancheswaran GOPALAKRISHNAN, Miles C. ANDREWS, Laurence ZITVOGEL, Valerio IEBBA
Estimating the term…
Described herein are methods and compositions for treating cancer and for predicting a subjects' response to combination checkpoint inhibitor therapy. Aspects of the disclosure relate to a method of treating cancer and/or reducing toxicity to a therapy in a subject comprising administering to the subject a composition comprising at least one isolated or purified population of bacteria belonging to one or more of the genera Flavonifractor, Dielma, Akkermansia, Alistipes, Bacteroides, Butyricimonas, Vampirovibrio, Tyzzerella, Parabacteroides distasonis, Fournierella, Fournierella massiliensis, Eisenbergiella tayi, Tissierellales, Hungateiclostridium thermocellum, Dorea formicigenerans, Caloramator coolhaasi, Muricomes, Geosporobacter, Prevotella paludivivens, Lactobacillus secaliphilus, Bacteroides fmegoldii, Lactobacillus johnsonii, Parapedobacter composti, and Anaerotignum lactatifermentans and wherein the method further comprises treating the subject with a combination of (i) a PD-1, PDL1, or PDL2 inhibitor and (ii) a CTLA-4, B7-1, or B7-2 inhibitor.
A method of treating cancer in a subject comprising:
A method of treating cancer in a subject comprising administering to a subject determined to have a favorable microbial profile in the gut microbiome a combination of (i) a PD-1, PDL1, or PDL2 inhibitor and (ii) a CTLA-4, B7-1, or B7-2 inhibitor.
A method for predicting a response to combination immune checkpoint inhibitor therapy in a subject having cancer, the method comprising:
A method for predicting a response to combination immune checkpoint inhibitor therapy in a subject having cancer, the method comprising:
A method comprising detecting one or more of Bacteroides stercoris, Bacteroides caccae, Bacteroides intestinalis, Dialister, Bacteroides fragilis, Vampirovibrio, Tyzzerella, Flavonifractor plautii, Dielma fastidiosa, Butyricimonas faecihominis, Alistipes, Akkermansia muciniphila, Lactobacillus rogosae, Prevotella copri, Prevotella shahii, Citrobacter, Clostridium hylemonae, Hungateiclostridium aldrichii, Citrobacter rodentium, Eubacterium sulci, Hafniaceae, Citrobacter freundii, Eubacterium halii, Enterobacter cloacae, Hafnia alvei, Hafnia, Roseburia hominis, Weissella paramesenteroides, Enterobacter, Bacilli, Lactobacillales, Klebsiella aerogenes, Klebsiella, Coprobacter, Intestinibacter bartletti, Intestinibacter, Parasutterella secunda, Dialister propionicifaciens, Parabacteroides distasonis, Fournierella, Fournierella massiliensis, Bacteroides coprophilus, Eisenbergiella tayi, Tissierellales, Hungateiclostridium thermocellum, Dorea formicigenerans, Caloramator coolhaasi, Muricomes, Muricomes intestini, Geosporobacter, Geosporobacter subterraneus, and Anaerotignum lactatifermentans in a subject.
A composition comprising at least one isolated or purified population of bacteria belonging to one or more of the genera or species Flavonifractor, Dielma, Akkermansia, Alistipes, Bacteroides, Butyricimonas, Vampirovibrio, Tyzzerella, Parabacteroides distasonis, Fournierella, Fournierella massiliensis, Eisenbergiella tayi, Tissierellales, Hungateiclostridium thermocellum, Dorea formicigenerans, Caloramator coolhaasi, Muricomes, Geosporobacter, Prevotella paludivivens, Lactobacillus secaliphilus, Bacteroides finegoldii, Lactobacillus johnsonii, Parapedobacter composti, and Anaerotignum lactatifermentans.
A composition comprising at least one isolated or purified population of bacteria belonging to one or more of the genera or species genera or species Flavonifractor, Bacteroides, Butyricimonas, Dielma, Akkermansia, Alistipes, Bacteroides stercoris, Parabacteroides distasonis, Fournierella, Fournierella massiliensis, Bacteroides coprophilus, Eisenbergiella tayi, Tissierellales, Hungateiclostridium thermocellum.
A composition comprising at least two isolated or purified population of bacteria belonging to one or more of the genera or species Flavonifractor, Dielma, Akkermansia, Alistipes, Bacteroides, Butyricimonas, Vampirovibrio, Tyzzerella, Parabacteroides distasonis, Fournierella, Fournierella massiliensis, Eisenbergiella tayi, Tissierellales, Hungateiclostridium thermocellum, Dorea formicigenerans, Caloramator coolhaasi, Muricomes, Geosporobacter, Prevotella paludivivens, Lactobacillus secaliphilus, Bacteroides finegoldii, Lactobacillus johnsonii, Parapedobacter composti, and Anaerotignum lactatifermentans.
A composition comprising at least two isolated or purified populations of bacteria belonging to two or more of the genera or species genera or species Flavonifractor, Bacteroides, Butyricimonas, Dielma, Akkermansia, Alistipes, Bacteroides stercoris, Parabacteroides distasonis, Fournierella, Fournierella massiliensis, Bacteroides coprophilus, Eisenbergiella tayi, Tissierellales, Hungateiclostridium thermocellum.
Dependencies are inferred from the claim text.