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AssigneeOsiris Therapeutics, Inc.
InventorsAlla DANILKOVITCH, Yi DUAN-ARNOLD, Matthew MOORMAN, Anne LERCH, Jin-Qiang KUANG
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Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.
A method of repairing damaged tissue, the method comprising applying a composition comprising an amniotic epithelial layer from an umbilical cord to the damaged tissue, wherein the damaged tissue is soft tissue, wherein the composition does not contain blood vessels, and wherein the composition does not contain viable cells.
A method of attaching a composition comprising an amniotic epithelial layer from an umbilical cord to soft tissue of a subject, the method comprising attaching the composition comprising the amniotic epithelial layer to the soft tissue of the subject wherein the composition does not contain blood vessels and does not contain viable cells.
Dependencies are inferred from the claim text.