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US 2022/0016175 A1Published application
Stem cell-derived extracellular vesicles and methods of use thereof
AssigneeWashington University
InventorHua Shen
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Abstract
Disclosed herein are bionanoparticles of adipose-derived stem cell extracellular vesicles, a tissue repair matrix comprising the bionanoparticles, and methods of use thereof for enhanced tendon healing.
Claims20
A bionanoparticle for enhanced musculoskeletal healing in a patient comprising at least one isolated extracellular vesicle (EV) from adipose-derived mesenchymal stromal cells (ASCs).
A method of preparing a tissue repair matrix comprising:
- harvesting a plurality of ASCs;
- culturing and inducing the harvested ASCs;
- isolating a plurality of EVs from the ASCs;
- and
- loading a collagen sheet with the plurality of EVs.
2 more elements
Dependencies are inferred from the claim text.