Method of administration and treatment
AssigneeDyve Biosciences, Inc.
InventorRyan BEAL
Life of this patent
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Abstract
Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
Claims20
A formulation suitable for transdermal delivery of a buffering agent, the formulation comprising the buffering agent and comprising benzyl alcohol and/or steric acid;
- wherein the buffering agent comprises sodium bicarbonate or sodium carbonate.
A formulation suitable for transdermal delivery of a buffering agent comprising sodium bicarbonate or sodium carbonate, the formulation comprising about 33% w/w sodium bicarbonate;
- about 1% w/w benzyl alcohol;
- about 0.5% w/w menthol;
- from about 1.5% to about 2% w/w stearic acid;
- and about 3% w/w almond oil;
- wherein the formulation further comprises one or more of cetyl alcohol, lecithin, isopropyl palmitate (IPP), ethanol, propylene glycol, a poloxamer, water, NaOH, and Durosoft®;
- and
- wherein the formulation is formulated as a cream, lotion, or ointment.
Dependencies are inferred from the claim text.