Method for preventing oral cancer
OwnerYu Zhou, Xiaobing Guan +1inventors
InventorsYu Zhou, Xiaobing Guan, Li Chen
Life of this patent
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Abstract
Disclosed are a method for preventing and treating oral cancer with an exosome carrying miR-185, and a pharmaceutical composition which contains a modified salivary exosome and is used for preventing and treating oral cancer.
Claims22
A method for prophylaxis or prevention of transformation from oral leukoplakia to oral cancer comprising administering to a leukoplakia subject a therapeutically effective amount of an exosome carrying miR-185.
A method for treatment of oral leukoplakia comprising administering to a leukoplakia subject a therapeutically effective amount of an exosome carrying miR-185.
9-12. (canceled)
A method for prophylaxis of oral cancer, comprising administering to a subject a prophylactically effective amount of an exosome carrying miR-185, wherein the exosome prevents the transformation of simple mucosal leukoplakia to leukoplakia with abnormal hyperplasia and oral cancer or prevents the transformation of leukoplakia with abnormal hyperplasia to oral cancer by one or more of the following mechanisms:
- inhibition of inflammation response, inhibition of oral mucosal epithelial cell abnormal hyperplasia, and inhibition of mucosal microangiogenesis.
(canceled)
A modified salivary exosome introduced with a prophylactically or therapeutically effective amount of miR-185.
22-24. (canceled)
A method for inhibiting the proliferation of oral cancer cells, comprising administering to a subject an effective amount of miR-185 or an exosome carrying miR-185 to inhibit the growth of oral cancer cells.
A method for regulating expression of oral cancer cell-associated proteins VEGF and AKT in a subject with oral cancer, comprising administering an effective amount of miR-185 or an exosome carrying miR-185 to the subject.
Dependencies are inferred from the claim text.