Compositions for the treatment of fibrosis and inflammation
AssigneeViking Therapeutics, Inc.
InventorsBrian Lian, Hiroko Masamune, Geoffrey E. Barker
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Abstract
The present disclosure is directed to methods of treating fibrotic conditions and inflammation by administration of TRβ agonists. The disclosure provides methods wherein the abnormal deposition of extracellular matrix components, such as collagen, keratin, or elastin, is reduced, either through interaction of TRβ agonists with TGF-β-dependent inflammatory pathways, or by other mechanisms, thereby ameliorating fibrotic symptoms.
Claims38
A method of treating fibrosis, a fibrotic condition or a fibrotic symptom in a subject in need thereof comprising administering one or more agonists of Thyroid Receptor Beta (TRβ) to said subject in need thereof.
A method of altering the level of expression of one or more fibrosis-related genes in a subject in need thereof comprising administering to the subject one or more agonists of Thyroid Receptor Beta (TRβ).
A method of treating fibrosis and inflammation in a subject in need thereof comprising administering one or more agonists of Thyroid Receptor Beta (TRβ) to said subject.
Dependencies are inferred from the claim text.