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US 2022/0016135 A1Published application
Treating breast cancer with hormone receptor modulators
AssigneeUniversity of Miami
InventorTan Ince
Life of this patent
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Abstract
The invention provides a classification and treatment system for breast cancer using measurements of and ligands for estrogen receptor, androgen receptor, vitamin D receptor, and optionally HER2 receptor.
Claims20
A method of treatment of breast cancer, the method comprising:
- measuring a level of estrogen receptor (ER), a level of androgen receptor (AR), and a level of vitamin D receptor (VDR) expressed in cancerous breast tissue obtained from a patient;
- detecting at least one of ER, AR, and VDR in the cancerous breast tissue obtained from the patient;
- and
- treating the patient with a cancer treatment regimen that includes:
- at least one ER antagonist ligand when the cancerous breast tissue expresses ER;
- at least one AR ligand when the cancerous breast tissue expresses AR;
- and
- at least one VDR agonist ligand when the cancerous breast tissue expresses VDR.
5 more elements
A method of treating breast cancer, comprising:
- measuring the level of estrogen receptor (ER), androgen receptor (AR), and vitamin D receptor (VDR) present in a breast cancer tumor of a patient,
- detecting at least one of ER, AR, and VDR in the breast cancer tumor,
- providing a therapeutically effective amount of at least one ER antagonist to the patient when ER is detected in the breast cancer tumor,
- providing a therapeutically effective amount of at least one AR ligand to the patient when AR is detected in the breast cancer tumor, and
- providing a therapeutically effective amount of at least one VDR agonist to the patient when VDR is detected in the breast cancer tumor.
2 more elements
Dependencies are inferred from the claim text.