Methods of treating depression, anxiety and sexual dysfunction using the compound pimavanserin

A method of treating major depressive disorder in a patient in need thereof, comprising

• orally administering once daily to the patient an effective amount of a compound selected from N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide or a pharmaceutically acceptable salt thereof.

A method of treating treatment-resistant major depressive disorder in a patient in need thereof, comprising

• orally administering once daily to the patient an effective amount of a compound selected from N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide or a pharmaceutically acceptable salt thereof.

A method of treating melancholic features with major depressive disorder in a patient in need thereof, comprising

• orally administering daily to the patient a compound selected from the group consisting of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and pharmaceutically acceptable salts thereof.

A method of treating generalized anxiety disorder in a patient in need thereof, comprising orally administering once daily to the patient an effective amount of a compound selected from N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide or a pharmaceutically acceptable salt thereof.

A method of treating a somatic symptom disorder in a patient in need thereof, comprising orally administering once daily to the patient an effective amount of a compound selected from N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide or a pharmaceutically acceptable salt thereof.

A method of treating an illness anxiety disorder in a patient in need thereof, comprising orally administering once daily to the patient an effective amount of a compound selected from N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide or a pharmaceutically acceptable salt thereof.

A method of treating anxious distress in a patient diagnosed with depression, comprising orally administering about 34 mg, once daily to the patient an effective amount of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide.

A method of treating depression in a patient in need thereof, wherein the patient is also suffering from Parkinson's disease, comprising

• orally administering to the patient 34 mg of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide once daily.

A method of treating depression associated with Parkinson's disease in an adult patient in need thereof comprising administering 34 mg of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide.

A method for the treatment of major depressive disorder comprising the administration of a therapeutically effective amount of pimavanserin or a pharmaceutically acceptable salt thereof to a patient in need thereof, wherein said patient has previously received a SSRI or a SRNI or is concurrently also being administered a SSRI or a SRNI for the treatment of the major depressive disorder and the SSRI or the SRNI has caused sexual dysfunction.

A method for the treatment of major depressive disorder comprising the administration of a therapeutically effective amount of pimavanserin or a pharmaceutically acceptable salt thereof to a patient in need thereof, wherein said patient has previously received a SSRI or a SRNI or is concurrently also being administered a SSRI or a SRNI for the treatment of the major depressive disorder and the SSRI or the SRNI has caused gastrointestinal or sleep related adverse events.

A method for treating selective serotonin reuptake SSRI or SNRI-induced sexual dysfunction in a human subject with SSRI or SNRI induced sexual dysfunction, the method comprising administering pimavanserin, or a pharmaceutically acceptable salt thereof, to the human subject.

A method for treating sexual dysfunction in a human subject with major depressive disorder comprising administering pimavanserin, or a pharmaceutically acceptable salt thereof, to the human subject.

A method of reducing sexual dysfunction in a human subject on antidepressant therapy comprising administering pimavanserin, or a pharmaceutically acceptable salt thereof, to the human subject.