Treatment of Hearing Loss by Inhibition of Casein Kinase 1
AssigneeMassachusetts Eye and Ear Infirmary
InventorsAlbert Edge, Yenfu Cheng
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Abstract
Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor.
Claims14
A method of treating a subject who has or is at risk of developing hearing loss or vestibular dysfunction, comprising administering to the subject one or more inhibitory nucleic acids that target casein kinase 1 (CK1) epsilon and/or CK1 delta, and one or more compounds that stimulate Atoh1 gene expression.
Dependencies are inferred from the claim text.