Methods for treating symptoms and disorders associated with lysosomal storage diseases

A method for treating or preventing supranuclear gaze palsies (e.g., associated with a lysosome storage disease), in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of formula (I),

• or a pharmaceutically acceptable salt or prodrug thereof, wherein:
• R1 is selected from hydrogen, halogen (e.g., fluorine), cyano, nitro, hydroxy, thio, amino, C1-6-alkyl (e.g., methyl or ethyl), C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyloxy, C2-6-alkenyloxy, and C2-6-alkynyloxy, wherein said alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, or alkynyloxy is optionally substituted with one or more (e.g., 1, 2 or 3) groups selected from halogen, cyano, nitro, hydroxy, thio or amino;
• R2 and R3 are independently selected from C1-3-alkyl, optionally substituted by one or more (e.g. 1, 2 or 3) halogens, or R2 and R3 together form a cyclopropyl or cyclobutyl group, optionally substituted by one or more (e.g. 1 or 2) halogens;
• R4, R5 and R6 are each independently selected from hydrogen, halogen, nitro, hydroxy, thio, amino, C1-6-alkyl, and C1-6-alkyloxy, wherein said alkyl or alkyloxy is optionally substituted by one or more (e.g. 1, 2 or 3) groups selected from halogen, hydroxy, cyano, and C1-6-alkyloxy;
• and
• A is a 5- or 6-membered aryl or heteroaryl group (e.g., phenyl or thiazolyl), optionally substituted with 1, 2 or 3 groups independently selected from halogen, hydroxy, thio, amino, nitro, C1-6alkoxy and C1-6alkyl.