Methods of treating cancers
AssigneeFoghorn Therapeutics Inc.
InventorsRichard C. CENTORE, Lan XU, David LAHR
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and compositions for the treatment of BAF-related disorders such as melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, and hematologic cancer.
Claims51
A method of treating melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, a hematologic cancer, or esophageal cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent that reduces the level and/or activity of BRG1 and/or BRM.
A method of reducing tumor growth of melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, a hematologic cancer, or esophageal cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent that reduces the level and/or activity of BRG1 and/or BRM in the tumor.
A method of suppressing metastatic progression of melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, a hematologic cancer, or esophageal cancer in a subject, the method comprising administering an effective amount of an agent that reduces the level and/or activity of BRG1 and/or BRM.
A method of suppressing metastatic colonization of melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, a hematologic cancer, or esophageal cancer in a subject, the method comprising administering an effective amount of an agent that reduces the level and/or activity of BRG1 and/or BRM.
A method of reducing the level and/or activity of BRG1 and/or BRM in a melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, hematologic cancer cell, or esophageal cancer cell, the method comprising contacting the cell with an effective amount of an agent that reduces the level and/or activity of BRG1 and/or BRM in the cell.
Dependencies are inferred from the claim text.