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US 2022/0016042 A1Published application
Nanoalum particles containing a pegylated lipid sizing agent
AssigneeInfectious Disease Research Institute
InventorsNeal VAN HOEVEN, Traci MIKASA, Christopher B. FOX, Anwar AHNIYAZ, Mark T. ORR, Amit KHANDHAR
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Abstract
Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle ranges from about 1 nm to 450 nm. Such a nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.
Claims24
A nanoalum particle comprising:
- an aluminum salt;
- and
- a sizing agent comprises a PEG linked to a lipid;
- wherein a size of the nanoalum particle ranges from about 1 nm to about 450 nm, and wherein a weight ratio of the aluminum salt to the sizing agent is about 1:1-1:3.
1 more element
Dependencies are inferred from the claim text.