Colonic drug delivery formulation
AssigneeTillotts Pharma AG
InventorsFelipe Varum, Roberto Carlos Bravo González
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Abstract
A delayed release drug formulation for oral administration delivers a drug to the colon of a subject. The formulation includes a core containing a drug and a coating for the core. The coating contains an outer layer and an inner layer. The outer layer contains a film-forming enteric polymer having a pH threshold at about pH 6 or above, and the inner layer contains a film-forming non-ionic polymer that is soluble in intestinal or gastrointestinal fluid and a buffer agent in an amount from more than 20 wt % to about 60 wt % based on the dry weight of the non-ionic polymer.
Claims32
A delayed release drug formulation for oral administration to deliver a drug to the colon of a subject, said formulation comprising:
- a core and a coating for the core, the core comprising a drug and the coating comprising an outer layer and an inner layer,
- wherein the outer layer comprises a film-forming enteric polymer having a pH threshold at about pH 6 or above, and
- wherein the inner layer comprises a first film-forming non-ionic polymer that is soluble in intestinal or gastrointestinal fluid, and a buffer agent in an amount of more than about 20 wt % to about 60 wt %, based on the dry weight of the first non-ionic polymer.
Dependencies are inferred from the claim text.