US 2022/0015816 A1 · High-Temperature Cryosurgery System and Methods of Using the Same

Abstract

A high temperature cryosurgery system and method of operation comprising a refrigeration assembly, a cryoprobe and a refrigerant wherein the cryoprobe and the refrigeration assembly are fluidly coupled in a closed loop configured to cycle the refrigerant in a fluid state from the refrigeration assembly to the cryoprobe and further configured to cycle the refrigerant in a vapor state from the cryoprobe to the refrigeration assembly. A method for treating cancer tumors and metastatic cancer cells by disrupting the tumor by sequentially or concurrently administering an ablative energy in combination with immunomodulation and/or pharmacological application, in one or more cycles, where the physical disruption is applied at levels sufficient to create the abscopal effect. That effect is generated by stimulating the immune cells in the microenvironment. The tumor is treated in a way permitting the remaining cells or elements in the tumor microenvironment to exert net immune stimulation with also long-term memory cells to fight subsequent appearing tumor in the future. Adding immune modulators injected in situ systemically or embedded in slow releasing means locally or systemically will boost the immune response to the cancer.

Claims20

Dependent claims

A cryosurgery system comprising:

a. a refrigeration assembly;
b. an operator probe having a housing, a fluid chamber, a fluid inlet communicating with the fluid chamber, a vapor chamber;
a fluid outlet communicating with the vapor chamber;
a fluid conduit in communication with the fluid inlet and a vapor conduit in communication with the vapor outlet;
c. a cryoneedle operably coupled to the housing of the operator probe and in communication with the fluid inlet and the vapor chamber of the operator probe;
d. a refrigerant contained within the fluid chamber, the vapor chamber, the fluid conduit and the vapor conduit;
and
wherein the operator probe and the refrigeration assembly are fluidly coupled in a closed loop configured to cycle the refrigerant in a fluid state from the refrigeration assembly to the operator probe and further configured to cycle the refrigerant in a vapor state from the operator probe to the refrigeration assembly.

5 more elements

A method of using a cryosurgery system having a refrigeration assembly, a cryoprobe, and a refrigerant, wherein the cryoprobe and the refrigeration assembly are fluidly coupled in a closed loop configured to cycle the refrigerant in a fluid state from the refrigeration assembly to the cryoprobe and further configured to cycle the refrigerant in a vapor state from the cryoprobe to the refrigeration assembly, the method comprising the steps of:

a. cooling the refrigerant in a fluid state;
b. cycling the refrigerant in a fluid state from the refrigeration assembly through a fluid conduit fluidly coupled to a fluid refrigerant intake of the cryoprobe, through the a fluid refrigerant intake into a fluid refrigerant chamber, the fluid refrigerant chamber having a cryoprobe having a cryoprobe body and cryoprobe tip at a distal end, the cryoprobe body partially disposed within the fluid refrigerant chamber;
c. cooling the cryoprobe;
d. conducting heat through the cryoprobe tip to the refrigerant;
e. vaporizing the refrigerant into a vapor mix chamber of the cryoprobe;
and
f. cycling the vaporized refrigerant through a vapor exhaust of the vapor mix chamber to the refrigeration assembly fluidly coupled to the vapor exhaust.

4 more elements

Dependencies are inferred from the claim text.

High-Temperature Cryosurgery System and Methods of Using the Same

Life of this patent

High-Temperature Cryosurgery System and Methods of Using the Same

Life of this patent

Abstract

Claims20