Systems and methods for minimally invasive delivery and in vivo creation of biomaterial structures

A method of stoma closure, the method comprising:

• insert, with a stoma closure tool comprising a drive module, a phase transition inducement module (PTIM), a conduit that defines a lumen, and a tensioning module, a distal end of the conduit through a first tissue and into a second tissue that together at least partially define a stoma;
• control, by the drive module, a flow rate of a fluid biomaterial through the lumen and discharged at the distal end of the conduit;
• and,
• induce, by the PTIM a fluid to solid phase transition in the fluid biomaterial such that the discharged biomaterial forms at least one continuous structure extending directly across the stoma between a proximal anchor in the first tissue and a distal anchor in the second tissue,
• wherein after formation of the distal anchor, the tensioning module applies tension to the at least one continuous structure such that the distal anchor urges the second tissue and the first tissue towards one another.