Method of identifying tumor drug resistance during treatment

A method of using tumor oxygenated perfusion percentage (OPP %) and volume change ratio (Vt %) of a particular solid tumor for assisting evidence-based tumor precision medicine, the method comprising:

• a. building up a OPP %-Vt % response database of different tumor responses to a treatment scheme, exploring the relationship between the measured tumor response information (oxygenated perfusion percentage (OPP %) and volume change ratio (Vt %) and their clinical outcomes of the treatment scheme;
• b. measuring multiple continuous measurements of the oxygenated perfusion percentage (OPP %) and a volume change ratio (Vt %) data with the treatment scheme;
• c. determining next treatment plan based on the measurement of individual tumor OPP % and Vt % data and the tumor OPP %-Vt % response database;
• and
• d. wherein the method is performed by one or more electronic devices.

A method of identifying the type of tumor drug resistance during a treatment scheme for a particular solid tumor, wherein it is applicable to all blood-borne therapies and local irradiation therapy except surgery, the method comprising:

• a. completing multiple continuous measurements during the same treatment scheme, wherein each oxygenated perfusion percentage (OPP %) and volume change ratio (Vt %) are obtained and plotted on an OPP %-Vt % coordinate graph of a cancer treatment response information diagram;
• b. continuously analyzing the multiple data sets and plotting them on the OPP %-Vt % coordinate graph as the treatment scheme progresses;
• c. retrospectively analyzing at least the latest two consecutive detection points of tumor OPP %-Vt % data, wherein if the consecutive measurements show that the tumor increases (Vt % is positive value) or the tumor continues to shrink (Vt % is negative value) and their difference is less than the critical value (3%), it is determined that the tumor is developing treatment resistance, and wherein identifying the type of tumor treatment resistance comprises the following steps:
• i. if at least two consecutive measurements show that the tumor increases (Vt % is positive value) or the tumor continues to shrink (Vt % is negative value) and their difference is less than the critical value (3%) and the oxygenation perfusion percentage (OPP %) are all less than a critical value (5%), the resistance can be identified as the type of a pharmacological/physiological factors (low drug distribution and poor tumor microcirculation);
• and
• ii. if at least two consecutive measurements show that the tumor increases (Vt % is positive value) or the tumor continues to shrink (Vt % is negative value) and their difference is less than the critical value (3%) and the oxygenation perfusion percentage (OPP %) data are all greater than a critical value (20%), the drug resistance can be identified as the type of a cell-specific factors;
• and
• d. wherein during tumor treatment, drug resistance of the solid tumor and its type may change dynamically in response to different treatment schemes, and multiple measurements are necessary for timely and accurate identification of tumor drug resistance and its type.