Method for preparing at least one generator with a high radium-228 content
AssigneeOrano Med
InventorsJulien Torgue, Rémy Dureau
Life of this patent
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Abstract
A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.
Claims23
A method for preparing at least one generator comprising radium-228 from an aqueous solution A1 comprising thorium-232 and radium-228, comprising at least the steps of:
- a) circulating in a first chromatography column a volume V1 of the aqueous solution A1, the first chromatography column comprising a first stationary phase consisting of a solid material which selectively retains radium with respect to thorium;
- b) washing at least once the first stationary phase with an aqueous solution A2;
- c) eluting the radium-228 from the first stationary phase with a volume V3 of an aqueous solution A3 comprising an agent complexing radium-228, the volume V3 being between 0.005% and 1% of the volume V1 of the aqueous solution A1 having circulated in the first chromatography column, whereby an aqueous solution A4 which comprises radium-228 complexes is obtained;
- d) dissociating the radium-228 complexes present in the aqueous solution A4 by modifying a pH of the aqueous solution A4, whereby an aqueous solution A5 comprising the radium-228 in a decomplexed form is obtained;
- e) loading a second chromatography column with the aqueous solution A5, the second chromatography column comprising a second stationary phase consisting of a same material as the first stationary phase;
- and
- f) washing at least once the second stationary phase with an aqueous solution A6, whereby the at least one generator is obtained.
Dependencies are inferred from the claim text.