Cellular diagnostic and analysis methods
AssigneeAquyre Biosciences, Inc.
InventorsBertrand LE CONTE CHRESTIEN DE POLY, Emilie BENOIT A LA GUILLAUME, Zoya I. VOLYNSKAYA
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Abstract
Detection of pathological abnormalities in tissue samples and/or pluralities of cells is a highly specialized and time-consuming effort, usually performed by a select group of clinicians and technical personnel. Described herein are methods for more automatable, consistent and comprehensive cell sample analysis to deliver a rapid, reliable and detailed classification, e.g., diagnosis, of the status of cells present in a sample, particularly, but not limited to cancer diagnosis.
Claims19
A method of determining the status of a plurality of cells, comprising:
- obtaining a time-dependent interferometric image and a spatially-dependent interferometric image of a plurality of cells suspected to comprise a cancerous cell;
- submitting the time-dependent interferometric image and the spatially-dependent interferometric image to a multi-layered algorithm analysis, thereby combining data associated at each pixel of the respective image of the plurality of cells;
- and
- automatically assigning a status to at least one cell of the plurality of cells, wherein the status is selected from a normal cell status or a cancerous cell status.
A method of performing a biopsy on a subject in need thereof, comprising:
- imaging a region of tissue to identify a region of interest;
- inserting a biopsy needle into the region of interest;
- excising a first tissue sample from the region of interest;
- obtaining a set of time-dependent interferometric images and a spatially-dependent interferometric image of the first tissue sample;
- and
- determining a number of cells of interest present within the first tissue sample.
Dependencies are inferred from the claim text.