Lens-free holographic optical system for high sensitivity label-free microbial growth detection and quantification for screening, identification, and susceptibility testing
AssigneeAccelerate Diagnostics, Inc.
InventorOleg Gusyatin
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Abstract
Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.
Claims21
(canceled)
An in-line holographic optical system comprising:
- a. a reference beam source;
- b. a sample receptacle below the reference beam source;
- c. an optical sensor below the sample receptacle;
- and
- d. a controller coupled to the optical sensor.
An in-line holographic system comprising:
- a. an illumination source;
- b. a sample receptacle below the illumination source;
- c. an optical sensor below the sample receptacle;
- and
- d. a hologram controller coupled to the optical sensor.
An in-line holographic imaging system comprising:
- a. at least two light sources;
- b. at least one reference beam source wherein the at least two light sources are situated to produce illumination with multiple wavelengths;
- and
- c. wherein the at least two light sources and the at least one reference beam source are arranged in relation to each other to produce illumination that overlaps at an optical sensor.
Dependencies are inferred from the claim text.