System for determining a health status of a tissue of interest
OwnerLian Chye Winston Koh, Stephen R. Quake +2inventors
InventorsLian Chye Winston Koh, Stephen R. Quake, Hei-Mun Christina Fan, Wenying Pan
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Abstract
The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected.
Claims26
A method for providing a clinical intervention for a pregnant subject, comprising:
- (a) obtaining a cell-free blood sample from said pregnant subject;
- (b) sequencing nucleic acid molecules derived from said cell-free blood sample to determine levels of a set of ribonucleic acid (RNA) transcripts;
- (c) comparing said levels of said set of RNA transcripts determined in (b) to reference levels of said set of RNA transcripts;
- (d) determining that said pregnant subject has or is at an elevated risk of having pre-eclampsia, based at least in part on said comparing in (c);
- and
- (e) providing said clinical intervention for said pregnant subject for said preeclampsia or said elevated risk of having said pre-eclampsia, based on said determining in (d).
Dependencies are inferred from the claim text.