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AssigneeNorth Carolina State University
InventorsCathrine Hoyo, David Skaar, Dereje Jima, Randy L. Jirtle
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Provided are compositions and methods for determining an imprinting status of a gene subject to parent-of-origin, monoalleleic expression in a subject, and for using the information derived therefrom to detect a presence of and/or a susceptibility to a medical condition associated with monoallelic expression in a subject, predict a susceptibility to future development of a medical condition prior to the onset of any symptoms, monitor the development of such a medical condition and/or the effectiveness of a treatment, and for treating such a medical condition. In some embodiments, a composition for use in the disclosed methods is nucleic acid array, which in some embodiments can include one or more interrogatable nucleotide molecules, wherein the interrogatable nucleotide molecules are designed to allow identification of the DNA methylation status of one or more imprint control regions (ICRs) that regulate one or more genes subject to monoalleleic expression in subjects.
1-6. (canceled)
A method for detecting a presence of and/or a susceptibility to a medical condition associated with monoallelic gene expression in a subject, the method comprising:
A method for predicting a susceptibility to future development of a medical condition associated with monoallelic expression in a subject prior to the onset of any symptoms of the medical condition in the subject, the method comprising:
A nucleic acid array comprising one or more interrogatable nucleotide molecules, wherein the interrogatable nucleotide molecules are designed to allow identification of the DNA methylation status of ICRs that regulate one or more genes subject to monoalleleic expression in a biological sample isolated from a subject.
Dependencies are inferred from the claim text.