A composition comprising mesenchymal stem cells for inhibiting adipogenesis
AssigneesCha University Industry-Academic Cooperation Foundation, Sungkwang Medical Foundation
InventorsGi Jin KIM, Jae Yeon KIM, He Len LEW
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Abstract
Provided is a composition for inhibiting, preventing, alleviating, or treating adipogenesis. Mesenchymal stem cells according to one aspect or a composition comprising the same inhibit fat accumulation or adipose tissue increase and thus may be advantageously utilized in the prevention, treatment, or alleviation of diseases associated with abnormal fat metabolism.
Claims9
A mesenchymal stem cell secreting phosphatase of regenerating liver-1 (PRL-1) or overexpressing PRL-1 compared to a parent cell.
A pharmaceutical composition for preventing or treating a disease associated with abnormal adipogenesis or abnormal fat metabolic dysfunction, the pharmaceutical composition comprising a mesenchymal stem cell secreting phosphatase of regenerating liver-1 (PRL-1) or overexpressing PRL-1 compared to a parent cell.
A health functional food for alleviating or preventing a disease associated with abnormal adipogenesis or abnormal fat metabolic dysfunction, the health functional food comprising a mesenchymal stem cell secreting phosphatase of regenerating liver-1 (PRL-1) or overexpressing PRL-1 compared to a parent cell.
A method of inhibiting fat accumulation, the method comprising:
- administering a mesenchymal stem cell to a test animal in vivo or contacting the mesenchymal stem cell with cells in vitro, the mesenchymal stem cell secreting phosphatase of regenerating liver-1 (PRL-1) or overexpressing PRL-1 compared to a parent cell.
Dependencies are inferred from the claim text.