Loading patent…
AssigneeMerus N.V.
InventorsAlexander Berthold Hendrik BAKKER, Comellis Jacob Johannes Georgr BOL, Pieter Fokko VAN LOO, Lenardo Andres SIRULNIK, Emesto Isaac WASSERMAN
Estimating the term…
The disclosure relates to means and methods of treating a subject for a CLEC12A positive cancer. In some embodiments the method comprises treating the subject in need thereof with two or more administrations of a bispecific antibody that binds CD3 and CLEC12A, wherein in a first administration an first amount of the bispecific antibody is administered and wherein in each of the subsequent administrations the amount of bispecific antibody is higher than the amount of bispecific antibody in the first administration. In some embodiments CLEC12A positive cancer treatment methods are provided at intervals and dosing regimens that spare hemopoietic stem cell compartment allowing for recovery of normal CLEC12A positive hemopoietic cells.
A method of treating a subject for a CLEC12A positive cancer the method comprising treating the subject in need thereof with two or more administrations of a bispecific antibody that binds CD3 and CLEC12A, wherein in a first administration a first amount of the bispecific antibody is administered and wherein in subsequent administrations the amount of bispecific antibody is higher than the amount of bispecific antibody in the first administration.
A bispecific antibody that binds CD3 and CLEC12A for use in a method of treatment of CLEC12A positive cancer in a subject, wherein said treatment comprises two or more administrations of a bispecific antibody that binds CD3 and CLEC12A, wherein in a first administration an first amount of the bispecific antibody is administered and wherein in each of the subsequent administrations the amount of bispecific antibody is higher than the amount of bispecific antibody in the first administration.
A method of purging CLEC12A positive hemopoietic cells from a subject and repopulating the hemopoietic system of said subject with normal CLEC12A positive cells, the method comprising administering to the subject in need thereof a bispecific antibody that binds CD3 and CLEC12A at intervals thereby killing CLEC12A positive malignant cells, and stimulating hemopoietic stem cells and/or hemopoietic progenitor cells of said subject to repopulate said hemopoietic system with newly formed hemopoietic stem cell derived CLEC12A positive cells.
The subject is preferably a subject that is diagnosed to have acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS), myelofibrosis (MF) or myeloproliferative neoplasm blast phase (MPN-BP).
A method of preparing an autologous bone marrow cell graft for a subject that is being treated for a CLEC12A positive cancer, the method comprising incubating a bone marrow cell preparation of said subject with a bispecific antibody that binds CD3 and CLEC12A under conditions suitable for killing of CLEC12A positive cells and subsequently collecting bone marrow cells from said incubation.
A method of treating a CLEC12A positive cancer in a subject, the method comprising incubating a bone marrow cell preparation of said subject with a bispecific antibody that binds CD3 and CLEC12A under conditions suitable for killing of CLEC12A positive cells, treating the subject with an hemopoietic system ablative therapy and providing said subject with a bone marrow cell graft comprising said incubated bone marrow cells.
A method of providing a subject with a hemopoietic stem cell sparing cancer treatment the method comprising administering a bispecific antibody that binds CD3 and CLEC12A to the subject in need thereof.
Dependencies are inferred from the claim text.