Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
AssigneeAmbrx, Inc.
InventorsMingchao Kang, Yingchun Lu, Nickolas Knudsen, MD Harunur Rashid, Feng Tian
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Abstract
The present invention provides methods for targeting interleukin-10 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using an interleukin-10 (IL-10) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-10 receptor.
Claims45
An IL-10 polypeptide homodimer of two IL-10 polypeptides each comprising one or more non-naturally encoded amino acids, wherein said IL-10 polypeptides are linked via a linker covalently bonded to the non-natural amino acid of each IL-10 polypeptide.
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A method of making an IL-10 polypeptide, comprising contacting a first isolated polypeptide homodimer of IL-10 comprising one or more non-naturally encoded amino acids, and a second isolated polypeptide homodimer of IL-10 comprising one or more non-naturally encoded amino acids;
- and linking the first and second IL-10 polypeptides via a linker covalently bonded to the non-natural amino acid of each IL-10 polypeptide.
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An IL-10 polypeptide of SEQ ID NOs:10-44 comprising a non-natural amino acid.
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Dependencies are inferred from the claim text.